Synthesis and Characterization of Self-Assembling Amphiphiles for a Targeted Drug Delivery System to Treat Pancreatic Cancer
نویسنده
چکیده
Med Hypotheses 1988, 25 (2), 119-123.20. Nel, A.; Xia, T.; Madler, L.; Li, N., Toxic potential of materials at the nanolevel. Science2006, 311 (5761), 622-627.21. Shvedova, A. A.; Castranova, V.; Kisin, E. R.; Schwegler-Berry, D.; Murray, A. R.;Gandelsman, V. Z.; Maynard, A.; Baron, P., Exposure to carbon nanotube material: Assessmentof nanotube cytotoxicity using human keratinocyte cells. J Toxicol Env Heal A 2003, 66 (20), 1909-1926.22. Drug Delivery in Oncology: From Basic Research to Cancer Therapy. Wiley-VCHVerlag & Co. KGaA: Weineim, 2012; Vol. 1.23. Antonian, L.; Burton, K.; Goodin, R.; Bentley, M.; Eldon, M. A., PEGylation governs thedisposition and metabolism of irinotecan following administration of a novel PEG-irinotecanconjugate. Ejc Suppl 2007, 5 (4), 115-115. 24. Schluep, T.; Hwang, J.; Cheng, J. J.; Heidel, J. D.; Bartlett, D. W.; Hollister, B.; Davis,M. E., Preclinical efficacy of the camptothecin-polymer conjugate IT-101 in multiple cancermodels. Clin Cancer Res 2006, 12 (5), 1606-1614.25. Mi, Z. H.; Burke, T. G., Differential Interactions of Camptothecin Lactone andCarboxylate Forms with Human Blood Components. Biochemistry-Us 1994, 33 (34), 10325-10336. 26. Shao, H.; Gao, M.; Kim, S. H.; Jaroniec, C. P.; Parquette, J. R., Aqueous Self-Assemblyof L-Lysine-Based Amphiphiles into 1D n-Type Nanotubes. Chem-Eur J 2011, 17 (46), 12882-12885.
منابع مشابه
Design, Synthesis and Characterization of Nano niosomal Delivery system Containing paclitaxel drug for Drug Delivery to Osteosarcoma Cell Line (Saos-2)
Introduction: Osteosarcoma is one of the cancers that current treatment strategies using chemotherapy drugs have not been very successful due to multiple drug resistance and harmful side effects. The use of nano-niosomal systems in the delivery of paclitaxel is one of the attractive approaches to overcome these limitations. paclitaxel is a powerful anticancer agent used in the treatment of many...
متن کاملApplication of mesoporous silica nanoparticles for drug delivery to cancer cells
Cancer is one of the main causes of death worldwide. Chemotherapy is the most common method for cancer therapy which represent non-specific side effects on normal cells and tissues and drug resistance in cancer cells. There are two main mechanisms for Multi Drug Resistance (MDR) in cancer cells including: drug efflux pump and activation of anti-apoptotic pathways. Cancer chemotherapy disadvanta...
متن کاملDesign and Construction of Ph-Sensitive Drug Delivery System Based on Metal-Organic Framework (MOF) Nanoparticles for Cancer Treatment by Drug Delivery System Containing Curcumin
Introduction: Much research has been carried out to improve drug delivery and targeted drug delivery to the body in order to minimize side effects, provide controlled delivery of the drug to the desired location and to achieve optimal therapeutic effects. Zeolitic imidazolate-8 (ZIF-8) is a subset of MOFs that are biocompatible, stable in the aquatic environment and have adjustable porosity. In...
متن کاملTruncated Hepatitis B virus like nanoparticles: A novel drug delivery platform for cancer therapy
Nowadays, Nano-sized drug delivery systems have been studied extensively for theirpotential in cancer therapy. Various drug nanocarriers are being developed including liposomes, micelles, and Virus like nanoparticles (VLNPs). VLNPs offer many advantages for developing smart drug delivery systems due to their precise and repeated structures and relatively large cargo capacities. Truncated ...
متن کاملDevelopment and characterization of rozuvastatin loaded self emulsifying drug delivery system for the effective management of hypolipidemia
The present work was aimed to develop and characterize rosuvastatin loaded self emulsifying drug delivery system for the effective management of hypolipidemia (RSEDDS) for improving bioavailability, to enhance solubility, to prolong residence time and to provide sufficient amount of drug to a target site in a sustained release manner. Self-emulsifying drug delivery system was prepared by simple...
متن کامل